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Fujio Shimizu Selected Research

nephrin

8/2009Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome.
7/2009Therapeutic targets in the podocyte: findings in anti-slit diaphragm antibody-induced nephropathy.
11/2008Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis.
6/2007Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall.
8/2006Role of podocyte slit diaphragm as a filtration barrier.
2/2006IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance.
6/2005Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy.
10/2004[Responsible genes for proteinuria and concept of the treatment for proteinuria].
8/2003Genetic polymorphism of NPHS1 modifies the clinical manifestations of Ig A nephropathy.
7/2003[Molecular mechanism responsible for the development of proteinuria: clinical significance of nephrin nephrotic syndrome].
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Fujio Shimizu Research Topics

Disease

25Proteinuria
01/2012 - 04/2002
19Glomerulonephritis
01/2009 - 05/2001
9Nephrotic Syndrome (Syndrome, Nephrotic)
08/2009 - 01/2002
5Nephritis
01/2007 - 11/2002
4Renal Insufficiency (Renal Failure)
04/2008 - 08/2003
4Fibrosis (Cirrhosis)
04/2008 - 12/2004
3Membranous Glomerulonephritis (Membranous Nephropathy)
08/2009 - 06/2005
3Disease Progression
04/2008 - 12/2004
2Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
08/2009 - 08/2006
2Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal)
08/2009 - 11/2008
2Inflammation (Inflammations)
11/2005 - 02/2004
2Body Weight (Weight, Body)
12/2004 - 04/2002
1Chronic Renal Insufficiency
02/2008
1Reperfusion Injury
01/2008
1Necrosis
01/2008
1Ureteral Obstruction
01/2007
1Stroke (Strokes)
09/2006
1Pancreatitis
08/2006
1Colitis
05/2006
1Kidney Diseases (Kidney Disease)
12/2004
1Brain Injuries (Brain Injury)
04/2004
1Nephrosis
04/2004
1Amyloidosis
08/2003

Drug/Important Bio-Agent (IBA)

13Monoclonal AntibodiesIBA
07/2009 - 04/2002
12nephrinIBA
08/2009 - 01/2002
6Proteins (Proteins, Gene)FDA Link
01/2008 - 08/2003
6Messenger RNA (mRNA)IBA
01/2007 - 04/2002
5NPHS2 proteinIBA
08/2009 - 01/2003
4Angiotensin IIIBA
08/2009 - 08/2005
4Transforming Growth Factor beta1 (TGF beta 1)IBA
02/2008 - 08/2004
4anti-Thy antibodyIBA
11/2005 - 11/2002
3Puromycin AminonucleosideIBA
02/2006 - 05/2002
2CD2-associated proteinIBA
08/2009 - 08/2006
2Interleukin-2 (IL2)IBA
01/2009 - 04/2002
2candesartanIBA
04/2008 - 03/2006
2Transforming Growth Factor beta (TGF-beta)IBA
04/2008 - 08/2004
2InterferonsIBA
01/2008 - 08/2006
2Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
01/2007 - 05/2006
2Therapeutic UsesIBA
05/2006 - 11/2002
2CytokinesIBA
01/2005 - 04/2002
1NucleotidesIBA
01/2012
1Complement System Proteins (Complement)IBA
07/2009
1GlycosidesIBA
01/2009
1Fibronectins (Fibronectin)IBA
04/2008
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2008
1Rosuvastatin Calcium (Crestor)FDA Link
04/2008
1Tissue Inhibitor of Metalloproteinase-1IBA
04/2008
1CollagenIBA
02/2008
1Sirolimus (Rapamycin)FDA Link
02/2008
1Immunoglobulin G (IgG)IBA
01/2008
1Neutralizing AntibodiesIBA
01/2008
1DNA (Deoxyribonucleic Acid)IBA
01/2007
1antiglomerular basement membrane antibodyIBA
01/2007
1Hydroxyproline (4 Hydroxyproline)IBA
01/2007
1ReninIBA
09/2006
1Peptides (Polypeptides)IBA
09/2006
1ChemokinesIBA
08/2006
1integrin-linked kinaseIBA
03/2006
1Probucol (Lorelco)FDA Link
03/2006
1NADPH Oxidases (NAD(P)H oxidase)IBA
03/2006
1AntioxidantsIBA
03/2006
1Sialic Acid Binding Ig-like Lectin 1IBA
12/2005
1GlucocorticoidsIBA
12/2005
1ElementsIBA
11/2005
1Captopril (Capoten)FDA LinkGeneric
11/2005
1Pharmaceutical PreparationsIBA
11/2005
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/2005
1p38 Mitogen-Activated Protein KinasesIBA
09/2005
1FR 167653IBA
09/2005
1Angiopoietin-1IBA
08/2005
1CreatinineIBA
08/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2005
1AntibodiesIBA
08/2005
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/2005
1podocalyxinIBA
06/2005
1Integrin alpha3IBA
06/2005
1CM-DiIIBA
04/2005
1saikosaponin DIBA
01/2005
1Silver Sulfadiazine (SSD)FDA LinkGeneric
01/2005
1sairei-toIBA
01/2005
1CilazaprilIBA
12/2004
1Mineralocorticoid Receptor AntagonistsIBA
12/2004
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
12/2004
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
12/2004
1Spironolactone (Aldactone)FDA LinkGeneric
12/2004
1Factor V (Coagulation Factor V)IBA
10/2004
1FibrinIBA
10/2004
1Catalytic DNA (Deoxyribozyme)IBA
08/2004
1SodiumIBA
04/2004
1Inositol (Myoinositol)IBA
04/2004
1SymportersIBA
04/2004
1Collagen Type I (Type I Collagen)IBA
03/2004
1Vitamin A (Retinol)FDA LinkGeneric
02/2004
1RetinoidsIBA
02/2004
1Retinoid X Receptors (Retinoid X Receptor)IBA
02/2004
1Retinoic Acid Receptor alphaIBA
02/2004
1Amyloidogenic ProteinsIBA
08/2003
1Low Density Lipoprotein Receptor-Related Protein-2IBA
08/2003

Therapy/Procedure

5Therapeutics
12/2005 - 04/2002
1Injections
09/2004